HORDB

ID: hor004136
Uniprot ID: Q9HD89(19-108)
Protein name: Resistin
Gene name: Retn
Organism: Homo sapiens (Human)
Family: Resistin/FIZZ family
Source: Human
Expression: Expressed in white adipose tissue (at protein level) .
Disease: NA
Comments: NA
Taxonomy: Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005515 protein binding
GO BP: GO:0007165 signal transduction; GO:0008150 biological_process; GO:0009612 response to mechanical stimulus; GO:0032868 response to insulin; GO:0045444 fat cell differentiation; GO:0050806 positive regulation of synaptic transmission; GO:2000252 negative regulation of feeding behavior; GO:2000872 positive regulation of progesterone secretion
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0035578 azurophil granule lumen; GO:0035580 specific granule lumen; GO:0070062 extracellular exosome

Sequence: KTLCSMEEAINERIQEVAGSLIFRAISSIGLECQSVTSRGDLATCPRGFAVTGCTCGSACGSWDVRAETTCHCQCAGMDWTGARCCRVQP
Length: 90(19-108)
Propeptide: MKALCLLLLPVLGLLVSSKTLCSMEEAINERIQEVAGSLIFRAISSIGLECQSVTSRGDLATCPRGFAVTGCTCGSACGSWDVRAETTCHCQCAGMDWTGARCCRVQP
Signal peptide: MKALCLLLLPVLGLLVSS
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes. Promotes chemotaxis in myeloid cells
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004136_AF2.pdb

hor004136_ESM.pdb

Mass:	1114160	Formula:	C393H637N121O130S13
Absent amino acids:	Y	Common amino acids:	C
pI:	5.76	Basic residues:	9
Polar residues:	37	Hydrophobic residues:	27
Hydrophobicity:	4	Boman Index:	-13960
Half-Life:	1.3 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	2 min	Aliphatic Index	65.11
Instability Index:	3447.78	Extinction Coefficient cystines:	11625
Absorbance 280nm:	130.62